HRs for type 2 diabetes risk across quartiles of the baseline PRAL and NEAP scores were estimated with multivariate Cox regression models. PRAL and NEAP scores were derived from nutrient intakes. A total of 66,485 women from the E 3 N-EPIC cohort were followed for incident diabetes over 14 years. The objective of this study was to evaluate the prospective relationship between dietary acid load, assessed with both the potential renal acid load (PRAL) and the net endogenous acid production (NEAP) scores, and type 2 diabetes risk. All rights reserved.ĭietary acid load and risk of type 2 diabetes: the E 3 N-EPIC cohort study.įagherazzi, Guy Vilier, Alice Bonnet, Fabrice Lajous, Martin Balkau, Beverley Boutron-Rualt, Marie-Christine Clavel-Chapelon, Françoise The presence of gastrointestinal transit disorders may assist in screening for subjects at higher risk of diabetes beyond the conventional risk factors. The present analysis showed, for the first time, a limited association between FGID and T2D risk in a large prospective cohort, and supports the hypothesis of a relationship between gastrointestinal function and diabetes. Also, these associations were independent of dietary habits such as coffee, fruit and vegetable consumption, and even of the use of laxatives and psychotropic drugs. There was no interaction between FGID and body mass index for risk of T2D. Compared with women who had normal gastrointestinal transits, women with chronic diarrhoea or alternating diarrhoea/constipation were at increased risk of T2D (HR: 1.29, 95% CI: 1.00-1.65 vs. A total of 1795 T2D cases were recorded during follow-up.
This analysis aimed to determine the influence of diarrhoea, constipation and alternating bouts of diarrhoea/constipation on T2D risk in 62,683 women from the prospective E 3 N-EPIC cohort. However, little is known of the association between FGID and type 2 diabetes (T2D) risk. Functional gastrointestinal disorders and incidence of type 2 diabetes: Evidence from the E 3 N-EPIC cohort study.įagherazzi, G Gusto, G Balkau, B Boutron-Ruault, M-C Clavel-Chapelon, F Bonnet, Fįunctional gastrointestinal disorders (FGID) such as diarrhoea and constipation can reflect intestinal dysfunction, especially with regard to intestinal microbiota, which, in turn, have been associated with chronic conditions, including obesity and insulin resistance.
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